TY - JOUR T1 - Altered pulmonary capillary blood volume in childhood sickle cell disease JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00379-2020 SP - 2000379 AU - Plamen Bokov AU - Priscilla Boizeau AU - Jade Pautrat AU - Florence Missud AU - Aissatou Ba AU - Zinédine Haouari AU - André Denjean AU - Christophe Delclaux AU - Malika Benkerrou Y1 - 2020/01/01 UR - http://erj.ersjournals.com/content/early/2020/06/11/13993003.00379-2020.abstract N2 - It has consistently been shown that patients with sickle cell disease (SCD) exhibit a compensatory increase in pulmonary capillary blood volume (PCBV), at least in a specific subgroup of patients [1]. This increase in PCBV could be related to the anaemia-induced increase in cardiac output [2]. Chaudry and colleagues showed that SCD patients failed to recruit and dilate their pulmonary capillary bed to the same extent as control subjects for a given rise in effective pulmonary blood flow [3]. One may therefore hypothesise that PCBV is already maximally recruited at rest; however, this is yet to be confirmed. Furthermore, it is not clear whether this potential defective pulmonary vascular recruitment is related to SCD history.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. BOKOV has nothing to disclose.Conflict of interest: Dr. BOIZEAU has nothing to disclose.Conflict of interest: Dr. PAUTRAT has nothing to disclose.Conflict of interest: Dr. MISSUD has nothing to disclose.Conflict of interest: Dr. BA has nothing to disclose.Conflict of interest: Dr. HAOUARI has nothing to disclose.Conflict of interest: Dr. Denjean has nothing to disclose.Conflict of interest: Dr. DELCLAUX has nothing to disclose.Conflict of interest: Dr. Benkerrou has nothing to disclose. ER -