TY - JOUR T1 - Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00524-2020 VL - 55 IS - 5 SP - 2000524 AU - Rong-Hui Du AU - Li-Rong Liang AU - Cheng-Qing Yang AU - Wen Wang AU - Tan-Ze Cao AU - Ming Li AU - Guang-Yun Guo AU - Juan Du AU - Chun-Lan Zheng AU - Qi Zhu AU - Ming Hu AU - Xu-Yan Li AU - Peng Peng AU - Huan-Zhong Shi Y1 - 2020/05/01 UR - http://erj.ersjournals.com/content/55/5/2000524.abstract N2 - The aim of this study was to identify factors associated with the death of patients with COVID-19 pneumonia caused by the novel coronavirus SARS-CoV-2.All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital (Wuhan City, Hubei Province, China) between 25 December 2019 and 7 February 2020. Univariate and multivariate logistic regression was performed to investigate the relationship between each variable and the risk of death of COVID-19 pneumonia patients.In total, 179 patients with COVID-19 pneumonia (97 male and 82 female) were included in the present prospective study, of whom 21 died. Univariate and multivariate logistic regression analysis revealed that age ≥65 years (OR 3.765, 95% CI 1.201‒11.803; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95% CI 1.279‒4.747; p=0.007), CD3+CD8+ T-cells ≤75 cells·μL−1 (OR 3.982, 95% CI 1.761‒9.004; p<0.001) and cardiac troponin I ≥0.05 ng·mL−1 (OR 4.077, 95% CI 1.778‒9.349; p<0.001) were associated with an increase in risk of mortality from COVID-19 pneumonia. In a sex-, age- and comorbid illness-matched case–control study, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1 remained as predictors for high mortality from COVID-19 pneumonia.We identified four risk factors: age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1. The latter two factors, especially, were predictors for mortality of COVID-19 pneumonia patients.These data showed that age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1 were four risk factors predicting high mortality of COVID-19 pneumonia patients https://bit.ly/2Rh6Nqv ER -