PT  - JOURNAL ARTICLE
AU  - Du, Rong-Hui
AU  - Liang, Li-Rong
AU  - Yang, Cheng-Qing
AU  - Wang, Wen
AU  - Cao, Tan-Ze
AU  - Li, Ming
AU  - Guo, Guang-Yun
AU  - Du, Juan
AU  - Zheng, Chun-Lan
AU  - Zhu, Qi
AU  - Hu, Ming
AU  - Li, Xu-Yan
AU  - Peng, Peng
AU  - Shi, Huan-Zhong
TI  - Predictors of Mortality for Patients with COVID-19 Pneumonia Caused by SARS-CoV-2: A Prospective Cohort Study
AID  - 10.1183/13993003.00524-2020
DP  - 2020 Jan 01
TA  - European Respiratory Journal
PG  - 2000524
4099  - http://erj.ersjournals.com/content/early/2020/04/01/13993003.00524-2020.short
4100  - http://erj.ersjournals.com/content/early/2020/04/01/13993003.00524-2020.full
AB  - To identify factors associated with the death for patients with COVID-19 pneumonia caused by a novel coronavirus SARS-CoV-2.All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital, Wuhan City, Hubei Province, China, between December 25, 2019 and February 7, 2020. Univariate and multivariate logistic regression was performed to investigate the relationship between each variable and the risk for death of COVID-19 pneumonia patients.A total of 179 patients with COVID-19 pneumonia (97 male and 82 female) were included in the present prospective study, of whom 21 died. Univariate and multivariate logistic regression analysis revealed that age ≥65 years (odd ratio, 3.765; 95% confidence interval, 1.146‒17.394; p=0.023), preexisting concurrent cardiovascular or cerebrovascular diseases (2.464; 0.755‒8.044; p=0.007), CD3+CD8+ T cells ≤75 cell·μL−1 (3.982; 1.132‒14.006; p<0.001), and cardiac troponin I≥0.05 ng·mL−1 (4.077; 1.166‒14.253; p<0.001) were associated with an increase in risk of mortality of COVID-19 pneumonia. In the sex‒, age‒, and comorbid illness-matched case study, CD3+CD8+ T cells ≤75 cell·μL−1 and cardiac troponin I≥0.05 ng·mL−1 remained to be the predictors for high mortality of COVID-19 pneumonia.We identified four risk factors, age ≥65 years, preexisting concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T cells ≤75 cell·μL−1, and cardiac troponin I≥0.05 ng·mL−1, especially the latter two factors, were predictors for mortality of COVID-19 pneumonia patients.Our data showed that age ≥65 years, preexisting concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T cells ≤75 cell·µL−1, and cardiac troponin I≥0.05 ng·mL−1 were four risk factors to predict high mortality of COVID-19 pneumonia patients.