PT  - JOURNAL ARTICLE
AU  - Emmanouela Sdona
AU  - Jenny Hallberg
AU  - Niklas Andersson
AU  - Sandra Ekström
AU  - Susanne Rautiainen
AU  - Niclas Håkansson
AU  - Alicja Wolk
AU  - Inger Kull
AU  - Erik Melén
AU  - Anna Bergström
TI  - Dietary antioxidant intake in school age and lung function development up to adolescence
AID  - 10.1183/13993003.00990-2019
DP  - 2020 Feb 01
TA  - European Respiratory Journal
PG  - 1900990
VI  - 55
IP  - 2
4099  - http://erj.ersjournals.com/content/55/2/1900990.short
4100  - http://erj.ersjournals.com/content/55/2/1900990.full
SO  - Eur Respir J2020 Feb 01; 55
AB  - Dietary antioxidant intake has been hypothesised to influence lung function. The association between total antioxidant capacity (TAC) of the diet at age 8 years and lung function development up to 16 years in 2307 participants from the Swedish population-based birth cohort BAMSE (Children, Allergy, Milieu, Stockholm, Epidemiology) was investigated.Information on TAC was obtained from a food frequency questionnaire at 8 years. Lung function was measured by spirometry at 8 and 16 years, impulse oscillometry (IOS) and exhaled nitric oxide fraction (FeNO) at 16 years. Low lung function was defined as forced expiratory volume in 1 s (FEV1) z-score below the 25th percentile. Longitudinal associations between TAC and lung function were analysed by mixed effect models adjusted for potential confounders. Stratification by asthma at 8 years was performed to examine effect modification.The median TAC intake was 10 067 μmol Trolox equivalents (TE)·g−1, with males having a lower mean compared to females (9963 versus 10 819 μmol TE·g−1). In analyses of lung function change between 8 and 16 years, there were no statistically significant associations between TAC in tertiles and spirometry results for the total study population. Among children with asthma at 8 years (prevalence 7%), higher TAC was associated with higher mean FEV1 (0.46 sd, 95% CI 0.11–0.80) and decreased odds of low lung function at 16 years (OR 0.28, 95% CI 0.12–0.65). There were no associations between TAC and forced vital capacity or IOS/FeNO results.High dietary antioxidant intake in school age may be associated with improved lung function development from school age to adolescence among children with asthma.Dietary antioxidant intake at school age may influence lung function development as measured by FEV1 up to adolescence among children with asthma. In contrast, no association was observed among children without asthma. http://bit.ly/2CzEZ8W