RT Journal Article
SR Electronic
T1 The effects of marijuana smoking on lung function in older people
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1900826
DO 10.1183/13993003.00826-2019
VO 54
IS 6
A1 Wan C. Tan
A1 Jean Bourbeau
A1 Shawn D. Aaron
A1 James C. Hogg
A1 François Maltais
A1 Paul Hernandez
A1 Darcy D. Marciniuk
A1 Kenneth R. Chapman
A1 Teresa To
A1 J. Mark FitzGerald
A1 Brandie L. Walker
A1 Jeremy Road
A1 Liyun Zheng
A1 Guohai Zhou
A1 Trevor Yau
A1 Andrea Benedetti
A1 Denis O'Donnell
A1 Don D. Sin
A1 ,
YR 2019
UL http://erj.ersjournals.com/content/54/6/1900826.abstract
AB Background Previous studies have associated marijuana exposure with increased respiratory symptoms and chronic bronchitis among long-term cannabis smokers. The long-term effects of smoked marijuana on lung function remain unclear.Methods We determined the association of marijuana smoking with the risk of spirometrically defined chronic obstructive pulmonary disease (COPD) (post-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity ratio <0.7) in 5291 population-based individuals and the rate of decline in FEV1 in a subset of 1285 males and females, aged ≥40 years, who self-reported use (or non-use) of marijuana and tobacco cigarettes and performed spirometry before and after inhaled bronchodilator on multiple occasions. Analysis for the decline in FEV1 was performed using random mixed effects regression models adjusted for age, sex and body mass index. Heavy tobacco smoking and marijunana smoking was defined as >20 pack-years and >20 joint-years, respectively.Results ∼20% of participants had been or were current marijuana smokers with most having smoked tobacco cigarettes in addition (83%). Among heavy marijuana users, the risk of COPD was significantly increased (adjusted OR 2.45, 95% CI 1.55–3.88). Compared to never-smokers of marijuana and tobacco, heavy marijuana smokers and heavy tobacco smokers experienced a faster decline in FEV1 by 29.5 mL·year−1 (p=0.0007) and 21.1 mL·year−1 (p<0.0001), respectively. Those who smoked both substances experienced a decline of 32.31 mL·year−1 (p<0.0001).Interpretation Heavy marijuana smoking increases the risk of COPD and accelerates FEV1 decline in concomitant tobacco smokers beyond that observed with tobacco alone.Prolonged heavy marijuana smoking increases the risk of COPD and accelerates FEV1 decline in concomitant tobacco cigarette smokers beyond the effects of tobacco alone http://bit.ly/2lI2lEu