RT Journal Article
SR Electronic
T1 Neuromuscular efficiency during exercise in COPD patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA1646
DO 10.1183/13993003.congress-2019.PA1646
VO 54
IS suppl 63
A1 Murillo Frazão de Lima e Costa
A1 Amilton Da Cruz Santos
A1 Flávia Maria Pinheiro Paulino
A1 Géssica Gomes Jerônimo
A1 Michel Platini Urtiga Romualdo
A1 Alex Andrade Araújo
A1 Maria Do Socorro Brasileiro-Santos
YR 2019
UL http://erj.ersjournals.com/content/54/suppl_63/PA1646.abstract
AB Introduction: Neural control of respiratory and peripheral muscles is affected by COPD resulting in altered neural drive and abnormal motor unit activation.Aims: To investigate neuromuscular efficiency in respiratory and peripheral muscles during exercise in COPD patients. Our hypothesis is that COPD patients have lower neuromuscular efficiency compared to healthy subjects.Methods: 12 COPD patients (FEV1:39 ± 13%) and 12 healthy subjects were enrolled. Neuromuscular activity was analyzed by electromyography (EMG) of diaphragm and vastus lateralis during cardiopulmonary exercise test. EMG data was normalized (%mV) by root mean square value at maximum work rate. Respiratory neuromuscular efficiency was determined by relationship between tidal volume and diaphragm EMG (mL/%mV). Peripheral neuromuscular efficiency was determined by relationship between work rate and vastus lateralis EMG (watts/%mV).Results: COPD presented lower respiratory neuromuscular efficiency above 50% exercise intensity (p < 0.01). COPD presented lower peripheral neuromuscular efficiency above 25% exercise intensity (p < 0.01) (figure).Conclusion: COPD patients have lower respiratory and peripheral neuromuscular efficiency from moderate and light exercise intensity, respectively, compared to healthy subjects.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA1646.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).