PT  - JOURNAL ARTICLE
AU  - Adriana Manrique Mutiozabal
AU  - Ana Hernandez
AU  - Juan Margallo
AU  - Isabel Pina
AU  - Fernando Revuelta
AU  - Manel Lujan
AU  - Victoria Villena
AU  - Javier Sayas
TI  - Non invasive ventilation (NIV) assisted exercise and neural drive in obstructive disease
AID  - 10.1183/13993003.congress-2019.PA4039
DP  - 2019 Sep 28
TA  - European Respiratory Journal
PG  - PA4039
VI  - 54
IP  - suppl 63
4099  - http://erj.ersjournals.com/content/54/suppl_63/PA4039.short
4100  - http://erj.ersjournals.com/content/54/suppl_63/PA4039.full
SO  - Eur Respir J2019 Sep 28; 54
AB  - Exercise in chronic obstructive pulmonary disease (COPD) is limited by dynamic hyperinflation and respiratory muscle overload leading to severe dyspnea. During exercise, increase in neural respiratory drive (NRD) is not able to match ventilatory demand, correlated with breathlessness. NIV may improve NRD uncoupling and exercise tolerance. We aimed to test if NIV during exercise reduced NRD, measured with paraesternal electromyography (EMG para); and improved dyspnea. We included 6 stable- hypercapnic patients with obstructive disease, candidates for lung transplantation. 10-minute cycle exercise at constant load was performed in spontaneous ventilation and under NIV. NRD and dyspnea were assessed every 3 minutes. Inter-subjects comparisons were made using repeated measures ANOVA. Demographic and funtional data expressed in mean± SD (Table). EMG para%max at end of exercise was 62.2% under spontaneous breathing and 57.4% under NIV; decrease in EMG activation under NIV was no estatistically significant (F=0.3, p=0.5) (Figure 1A). Near linear breathlessness pattern of increase was observed under NIV, with no differences among groups (F=0.79, p=0.39) (Figure 1B).View this table:FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4039.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).