TY - JOUR T1 - Circulating total leptin as a diagnostic and prognostic biomarker in sepsis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2019.PA2177 VL - 54 IS - suppl 63 SP - PA2177 AU - Irene Karampela AU - Evangelia Kandri AU - Evangelia Chrysanthopoulou AU - George Skyllas AU - Gerasimos-Socrates Christodoulatos AU - Georgios Antonakos AU - Evangelos Vogiatzakis AU - Apostolos Armaganidis AU - Maria Dalamaga Y1 - 2019/09/28 UR - http://erj.ersjournals.com/content/54/suppl_63/PA2177.abstract N2 - Introduction: Leptin, the first discovered adipokine, has been implicated in sepsis. However, very few prospective studies have investigated its role in sepsis.Aim: To investigate leptin’s association with sepsis severity and prognosis.Methods: We prospectively studied 102 critically ill patients (57 males, mean age 65±15years) fulfilling the diagnostic criteria of SEPSIS-3, and 102 age and gender-matched healthy controls. Serum leptin was determined by ELISA (BioVendor Laboratory Medicine Inc, Brno, Czech Republic) at sepsis onset and one week after. Statistical analysis was performed using IBM-SPSS® v. 24.Results: Sixty patients presented with sepsis and 42 with septic shock. Mean APACHE II was 23±7 and SOFA 10±3. Thirty patients died within 28 days (mortality 29.4%). At admission, leptin was significantly higher in patients compared to controls (27±8 ng/mL vs 12±9 ng/mL, p<0.001) and in septic shock compared to sepsis one week after (22±7 ng/mL vs 19±4 ng/mL, p<0.05). Leptin was higher in survivors than nonsurvivors both at baseline (29±8 ng/mL vs 23±6 ng/mL, p<0.001) and day 7 (21±6 ng/mL vs 19±5 ng/mL, p=0.013) and exhibited significantly positive correlations with APACHE II and SOFA scores. In univariate Cox regression analysis lower leptin at baseline and day 7 was significantly associated with 28-day mortality. Lower serum leptin at enrollment and day 7 was independently associated with 28-day mortality, after adjustment for age, gender, BMI, APACHE II score, presence of septic shock and significant laboratory biomarkers (p=0.03 and p=0.009, respectively).Conclusion: Leptin may predict severity and mortality in critically ill septic patients.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA2177.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -