TY - JOUR T1 - Early rehabilitation is associated with reduced in-hospital mortality from sepsis in patients with sarcopenia JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2019.PA2185 VL - 54 IS - suppl 63 SP - PA2185 AU - Jin-Hee Noh AU - Yun Seong Kim AU - Taehwa Kim AU - Jae Heun Chung AU - Jin Ook Jang AU - Hye Ju Yeo Y1 - 2019/09/28 UR - http://erj.ersjournals.com/content/54/suppl_63/PA2185.abstract N2 - Purpose: To determine whether intensive care unit (ICU) rehabilitation impacts clinical outcomes of sepsis in patients with and without sarcopeniaMethods: We enrolled 516 patients with sepsis who admitted in medical ICU between June 2011 and August 2017. Skeletal muscle area was calculated from psoas muscle cross-sectional area (cm2) at the level of the 3rd lumbar vertebra divided by the square of the patient’s height in meters to give the skeletal muscle index (SMI). Patients were divided into two subgroups (sarcopenic and non-sarcopenic patients), and in-hospital mortality was compared in patients conducted with and without ICU rehabilitation within each subgroup.Results: ICU rehabilitation(RH) was conducted to 51.1% sarcopenic patients and 54.7% non-sarcopenic patients. In-hospital mortality did not differ between non-sarcopenic patients with ICU RH and those without ICU RH (80.8% vs 67.4%, p=0.137), but was significantly lower in in sarcopenic patients with ICU RH than in those without ICU RH (74% vs 60.2%, p=0.003). Multivariate Cox regression showed that ICU RH was independently associated with reduced in-hospital mortality in sarcopenic patients (OR 0.49, 95% CI 0.35-0.69, p<0.001), but not in non-sarcopenic patients. Furthermore, ICU RH was independently associated with reduced in-hospital mortality in non-elderly patients with sarcopenia (OR 0.40, 95% CI 0.21-0.74, p=0.004), but not in elderly patients with sarcopenia.Conclusions: ICU rehabilitation could be more beneficial in sarcopenic patients. In particular, it could be more effective in the non-elderly.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA2185.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -