PT  - JOURNAL ARTICLE
AU  - Mariann Ulvestad
AU  - Michael Thomas Durheim
AU  - Johny Kongerud
AU  - May Brit Lund
AU  - Elisabeth Edvardsen
TI  - Effect of high intensity training after lung transplantation
AID  - 10.1183/13993003.congress-2019.PA3369
DP  - 2019 Sep 28
TA  - European Respiratory Journal
PG  - PA3369
VI  - 54
IP  - suppl 63
4099  - http://erj.ersjournals.com/content/54/suppl_63/PA3369.short
4100  - http://erj.ersjournals.com/content/54/suppl_63/PA3369.full
SO  - Eur Respir J2019 Sep 28; 54
AB  - Background: Physical fitness after lung transplantation (LTx) is often severely reduced, despite improvement in lung function. Low physical fitness is associated with increased mortality. We hypothesized that high-intensity training (HIT) would improve peak oxygen uptake (VO2peak) and muscular strength after LTx.Methods: In a randomized controlled trial, 54 LTx-recipients were enrolled 6-60 months after surgery. The HIT group (n=25) followed a 20-week endurance and strength training program three times a week. The control group (n=29) followed the hospital’s general recommendations for physical activity. All patients completed a maximal cardiopulmonary exercise test, arm- and leg press pre- and post-intervention. The primary outcome was change in VO2peak as a measure of cardiorespiratory fitness. Secondary outcomes were change in one-repetition maximum (1RM) in arm- and leg press as measures of muscular strength. ANCOVA was used for per-protocol analyses based on ≥70% attendance of the prescribed sessions. Data are presented as mean±SD.Results: VO2peak at baseline was 71±14 and 68±14% of predicted in the HIT- and control group, respectively. No adverse outcomes related to HIT were reported.View this table:Conclusion: HIT improved VO2peak and muscular strength. HIT may represent an effective form of exercise therapy that improves physical fitness and health outcomes after lung transplantation.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA3369.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).