RT Journal Article
SR Electronic
T1 Less sun, more cough: Annual hours of sunshine are inversely associated with hospital admissions for children with lower respiratory tract infection
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP OA4970
DO 10.1183/13993003.congress-2019.OA4970
VO 54
IS suppl 63
A1 James Walker
A1 Fran Gilchrist
A1 Will Carroll
YR 2019
UL http://erj.ersjournals.com/content/54/suppl_63/OA4970.abstract
AB Background: Vitamin D deficiency affects immune function increasing susceptibility to respiratory tract infections (RTI). Randomised controlled trials show vitamin D supplementation protects against acute RTIs. Most vitamin D (>90%) is acquired from sun exposure.Objective: To determine whether there is an association between hours of sunshine, deprivation status and severe lower respiratory tract infection rates (LRTI) in English children.Methods: The annualised age-gender corrected severe LRTI (agc-LRTI) rate for children <15 years was determined using Hospital Episodes Statistics data for April 2002-2011. Hours of sunshine (HoS) were calculated for matched regions using Met Office data. Regional deprivation index scores (IDACI) were taken from DoH statistics. Multivariate regression was used to explore the relationship between HoS, agc-LRTI rate & IDACI.Results: During the study period 314,226 children were admitted to English hospitals with LRTI. The child population varied between 9,654,027 and 9,853,580. The mean agc-LRTI rate was 357/100,000. The annual HoS in each region varied between 1287 hours (NW 2008-9) and 1815 hours (SE & Central 2006-7). There was a strong inverse association between HoS and agc-LRTI admission rates in English regions (p<0.001). In the model regional deprivation showed no statistical association with severe LRTI rate (p=0.54).Conclusion: Long-term weather patterns are associated with admissions to hospital for children with LRTI. Sunnier regions and sunnier years have lower LRTI admission rates when correcting for age, gender and deprivation. It is biologically plausible that this effect is mediated by vitamin D.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, OA4970.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).