RT Journal Article SR Electronic T1 Sporadic coronavirus lower respiratory tract infection in adults: chest CT imaging features and comparison with other viruses JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA4547 DO 10.1183/13993003.congress-2019.PA4547 VO 54 IS suppl 63 A1 Lawrence A. Marinari A1 Madeline A. Danny A1 Wallace T. Miller, Jr. YR 2019 UL http://erj.ersjournals.com/content/54/suppl_63/PA4547.abstract AB Coronavirus(CoV) has been associated with lower respiratory tract infection(LRTI) in adults worldwide. The CoV associated with Sudden Acute Respiratory Syndrone and Middle East Respiratory Syndrone typically cause ground-glass opacities(GGO) and/or consolidation on chest CT. Chest CT features of sporadic CoV(subtypes: HKU1, NL63, OC43, 229E) have not been characterizedc. Our aims were to characterize chest CT features of sporadic CoV and compare these findings with those from other viruses. We retrospectively reviewed the records and chest CT images of 61 adults over 32 months at 4 community hospitals in the northeast US. CT images were reviewed by an experienced thoracic radiologist. Study subjects satisfied 4 criteria: 1) symptoms of acute LRTI, 2) positive polymerase chain reaction assay for CoV, 3)CT within 7 days of positive assay for CoV, 4)no other pulmonary infection or other pulmonary disease that might interfere with CT interpretation. We compared the chest CT features of sporadic CoV with those we previously reported for adenovirus, influenza, human metapneumovirus (hMPV), parainfluenza virus (PIV) and respiratory syncytial virus. On review of CoV cases, 11(18%) had bronchial wall thickening, 15(25%) had GGO, 12(20%) had lung consolidation and 13(21%) had tree-in-bud opacities. Twenty-eight(46%) had no chest CT findings related to acute infection. Sporadic CoV was similar to influenza but different from PIV (p<.05) and hMPV (p<.05) in causing acute LRTI symptoms without chest CT abnormalities. When sporadic CoV did cause CT abnormalities there was no predominant pattern which was similar to influenza but different from other viruses we studied.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4547.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).