PT  - JOURNAL ARTICLE
AU  - Francisco Sanz Herrero
AU  - Silvia Vicente Ferrer
AU  - María Luisa Briones
AU  - Marcelino Martínez
AU  - Jessica Lozada
AU  - Estrella Fernández Fabellas
AU  - Araceli Aibar
AU  - Santos Ferrer
AU  - Francisco Dasí Fernández
TI  - Circulating microRNAs can identify endotypes of community-acquired pneumonia
AID  - 10.1183/13993003.congress-2019.PA5449
DP  - 2019 Sep 28
TA  - European Respiratory Journal
PG  - PA5449
VI  - 54
IP  - suppl 63
4099  - http://erj.ersjournals.com/content/54/suppl_63/PA5449.short
4100  - http://erj.ersjournals.com/content/54/suppl_63/PA5449.full
SO  - Eur Respir J2019 Sep 28; 54
AB  - Background: The identification of the host processes dysregulated in community-acquired pneumonia (CAP) patients, especially in those who develop severe complications could be crucial for future management of this disease. We aim to study microRNAs profiles to define different CAP endotypes regarding complications.Methods: An observational prospective study of consecutive hospitalized CAP cases was performed. Circulating microRNAs were analyzed using qRT-PCR. We study correlations and predictive value of miRNAs regarding severe sepsis and acute hypoxemic respiratory failure (AHRF: PaO2/FiO2<250).Results: We analyzed clinical data and blood samples from 169 CAP patients. The mean age was 66.9 years (IQR: 58-79). The main comorbidities were diabetes (29%), COPD (28.4%), arrhythmia (13.6%), and cerebrovascular disease (8.9%). 97 patients (57.4%) presented severe CAP (PSI IV-V). Complications were found in 109 patients (64.5%): AHRF was present in 25.4%, and severe sepsis in 13.6%. Mortality was 3.6%. We found that miR 223 and miR 574 were downregulated in severe sepsis (AUC 0.78), and in AHRF (AUC 0.77) respectively. miR 182 downregulation had a high predictive value to predict both severe sepsis and AHRF (AUC 0.83 and 0.76) in hospitalized CAP patients.Conclusions: 1-We have identified different endotypes in CAP determined by circulating miRNAs profiles.2-The expression of miR-223, miR-574, and miR-182 are related to severe sepsis and AHRF in hospitalized CAP patients.Funded by: Sociedad Valenciana de NeumologíaFootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA5449.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).