PT  - JOURNAL ARTICLE
AU  - Irina Viktorova
AU  - Vera Zimina
AU  - Sergey Dolgikh
AU  - Svetlana Degtyareva
AU  - Arkadiy Khanin
TI  - Recurrent tuberculosis among HIV-infected patients in Novokuznetsk, Russia
AID  - 10.1183/13993003.congress-2019.PA2947
DP  - 2019 Sep 28
TA  - European Respiratory Journal
PG  - PA2947
VI  - 54
IP  - suppl 63
4099  - http://erj.ersjournals.com/content/54/suppl_63/PA2947.short
4100  - http://erj.ersjournals.com/content/54/suppl_63/PA2947.full
SO  - Eur Respir J2019 Sep 28; 54
AB  - The aim was to examine the characteristics of recurrent tuberculosis (TB) in HIV patients.Materials and Methods: retrospective study of all recurrent HIV/TB cases following cure or successful treatment completion (n=153) registered in 2013 -2017 in Novokuznetsk, Russia (regional TB incidence was 83,6/100 000, HIV/TB – 48,0% of all new TB cases). HIV/TB accounted to 46,4% of all registered recurrent TB (n=330).Results: pulmonary TB was registered in 150 cases (98,0%). Smear and/or culture positive were 112 (74,7%), MDR was in 65 (82,3% of all drug susceptibility tests (n=79) on Löwenstein-Jensen media using absolute concentration method). Median CD4 count was 114 cells/μl (1-718 cells/μl). Antiretroviral treatment (ART) was previously initiated in 72 patients (80,2%), adherent to ART prior to TB recurrence were only 13 (18,1%), 9 (12,5%) had irregular ART, and 50 (69,4%) missed ART for at least 6 months before TB recurrence. Culture negative or susceptible TB was treated with I line drugs. MDR TB treatment received 35 patients (53,8% of all MDR), the remaining 30 (46,2%) were not assigned to MDR treatment because of DST results received after death or non-compliance. TB treatment in patients with recurrent HIV/TB was successful in 23 cases (15,1%) (10 cured and 13 treatment completed), failure was in 17 (11,1%), 77 (50,3%) died, 7 (4,6%) were transferred out, 8 (5,2%) defaulted treatment, 17 (11,1%) continued antituberculous treatment and in 4 (2,6%) TB diagnosis was withdrawn. Mortality was higher in ART defaulters (62,0%) than in those compliant to ART (23,1%) before TB recurrence (Р=0,028).Conclusion: recurrent HIV/TB cases had high MDR and mortality rate, the majority were noncompliant to ART.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA2947.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).