TY - JOUR T1 - The role of salivary gland biopsy in the diagnosis of sarcoidosis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2019.PA1946 VL - 54 IS - suppl 63 SP - PA1946 AU - Gulfer Okumus AU - Zuleyha Bingol AU - Merve Sarisoy AU - Tulin Cagatay AU - Esen Kiyan AU - Zeki Kilicaslan Y1 - 2019/09/28 UR - http://erj.ersjournals.com/content/54/suppl_63/PA1946.abstract N2 - Introduction: Minor salivary gland biopsy is used as a minimally invasive method in the diagnosis of sarcoidosis. To date, a few studies have shown that minor salivary gland biopsy is an diagnostic tool in differentiating sarcoidosis from tuberculosis. In this study we evaluated the diagnostic yield of minor salivary gland biopsy in patients with sarcoidosis.Material and methods: The study included patients with sarcoidosis who were diagnosed during the last 10 years in Pulmonary Department of Istanbul Medical Faculty. Baseline diagnostic tests, histopathological results and clinical findings were recorded.Results: Totally, 354 patients (270 female, 84 male, mean age: 46.48) with sarcoidosis were analyzed. Radiologically, 7.3% was stage 0, 46.6% was stage I, 33% was stage II, 9% was stage III, and 3.9% was stage IV. Respiratory functions were normal in 70%, diffusion capacity was normal in 66% and 18.8% had obstructive pattern, 10.9% had restrictive pattern in spirometry. The most common extrapulmonary involvement was skin (%22.8) and eye (%16.9). Minor salivary gland biopsy was performed in 215 cases and 49.3% of them had findings compatible with sarcoidosis. In 13.8% of the cases, the diagnosis was based on only minor salivary gland biopsy and clinical-radiological findings.Conclusion: In our study, salivary gland biopsy was diagnostic in half of the cases, and in 13.8% of the cases was diagnosed without any other invasive procedure. Therefore, it can be used as a priority biopsy method in patients with clinical and radiological suspicion of sarcoidosis.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA1946.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -