PT  - JOURNAL ARTICLE
AU  - Kseniia Bielosludtseva
AU  - Tetiana Pertseva
AU  - Tetiana Kirieieva
AU  - Mariia Krykhtina
TI  - Dynamic changes of markers of endothelial function, hemostasis, fibrinolysis and inflammation in hospitalized patients with community-acquired pneumonia
AID  - 10.1183/13993003.congress-2019.PA5452
DP  - 2019 Sep 28
TA  - European Respiratory Journal
PG  - PA5452
VI  - 54
IP  - suppl 63
4099  - http://erj.ersjournals.com/content/54/suppl_63/PA5452.short
4100  - http://erj.ersjournals.com/content/54/suppl_63/PA5452.full
SO  - Eur Respir J2019 Sep 28; 54
AB  - The aim was to estimate the role of parameters of systemic inflammation (C-reactive protein(CRP), fibrinogen), endothelial dysfunction (endothelin 1(ET-1)), hemostasis (protein C(PC)), fibrinolysis (D-dimer(DD) on different phases of treatment in patients with CAP.Material and Methods: The main group was 75 patients(pts) with moderate to severe CAP. The main group were divided into: subgroup 1–41 pts(moderate CAP), subgroup 2–34 pts(severe CAP).Blood coagulation test, biomarkers was performed at admission before antibacterial treatment (visit 1) and after clinical stability on 7–10 day(visit 2).Results: Levels of systemic inflammation and coagulation parameters in patients with moderate to severe CAP, Me [25-75%]View this table:Conclusions:In-patient cases of CAP are characterized by systemic inflammation and hypercoagulation.Normalization of PC is coming after 7–10 days of antibacterial treatment of CAP, vice versa ET-1, which reflects prolong endothelial dysfunction in patients with severe CAP.ET-1 and PC can be useful for establishment of coagulation disorders in pts with CAP.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA5452.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).