PT  - JOURNAL ARTICLE
AU  - Haisheng Hu
AU  - Baoqing Sun
AU  - Huimin Huang
TI  - Diagnostic value of combined sIgG and sIgE of Aspergillus fumigatus in allergic broncho pulmonary aspergillosis and severe asthma with fungal sensitation
AID  - 10.1183/13993003.congress-2019.PA2755
DP  - 2019 Sep 28
TA  - European Respiratory Journal
PG  - PA2755
VI  - 54
IP  - suppl 63
4099  - http://erj.ersjournals.com/content/54/suppl_63/PA2755.short
4100  - http://erj.ersjournals.com/content/54/suppl_63/PA2755.full
SO  - Eur Respir J2019 Sep 28; 54
AB  - Objective: Allergic broncho pulmonary aspergillosis (ABPA) and Severe asthma with fungal sensitation (SAFS) is very similar in clinical symptoms. This study aims to explore the characteristic of these patients and accurate diagnosis between them.Methods: The specific immunoglobulin E (sIgE) of Aspergillus fumigatus was detected by Phadia 1000 system and the specific immunoglobulin E (sIgG) of A.fumigatus was detected by ELISA kit (DRG) in 17 patients with ABPA and 14 patients with SAFS.Results: The levels of sIgG [2294.00 U/mL (1527.00, 14170.00) vs. 972.60 U/mL (650.90, 1792.00)], sIgE [8.77 kU/L (1.64, 16.85) vs. 1.04 kU/L (0.70, 2.05)] in ABPA patients were significantly higher than those in SAFS patients (P < 0.0 5). A, fumigatus sIgG was strongly correlated with A.fumigatus sIgE (rs = 0.797, P < 0.001) in ABPA. When combined with A.fumigatus sIgG (> 1000.00 U/mL) and A.fumigatus sIgE (> 1.00 kU/L) for the differential diagnosis of ABPA and SAFS, the sensitivity and specificity reached 82.3% and 78.6%, respectively. There was no significant difference in blood routine, induced sputum and G test between ABPA and SAFS patients.Conclusion: ABPA patients have higher levels of sIgG and sIgE of A.fumigatus than SAFS patients. Combination of sIgG and sIgE of A.fumigatus to diagnosis ABPA and SAFS patients is important.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA2755.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).