%0 Journal Article %A Laura Petrarca %A Raffaella Nenna %A Antonella Frassanito %A Serena Arima %A Greta Di Mattia %A Alessandra Pierangeli %A Erika Marchionne %A Carolina Scagnolari %A Vincenzo Ferraro %A Agnese Viscido %A Serena Castaldi %A Fabio Midulla %T Heterogeneity of bronchiolitis: a clustering approach to identify different endotypes in hospitalized infants %D 2019 %R 10.1183/13993003.congress-2019.PA1004 %J European Respiratory Journal %P PA1004 %V 54 %N suppl 63 %X Introduction: Bronchiolitis is the most common cause of hospitalization in infants and recent evidences in literature suggest its heterogeneity.Aims and Objectives: Our aim was to investigate whether different clinical profiles exist among infants hospitalised with bronchiolitis.Methods: we consecutively enrolled children < 12 months of age hospitalised for acute bronchiolitis during the epidemic season 2017-2018. For each patient vital signs, physical examination, family history and laboratory results were collected. Bronchiolitis profiles were determined by latent class analysis (LCA) (R).Results: 176 infants participated in the study. LCA identified four profiles. Profile A (n=14) had the highest family history of atopy (asthma 94.5%, eczema 85%) and wheeze on chest auscultation (100%), with milder clinical presentation (need of oxygen therapy in 19.2% of cases). In contrast, profile B (n=58) identifies the most severely ill infants (need of oxygen in 100% of cases), with a lower family history of asthma (36.6%) and eczema (29.6%). Profile C (n=38) was similar to profile A, but with lower family history of atopy (asthma in 47.5% and eczema in 44.4%). Profile D patients (n=66) were similar to profile B, but with no need of oxygen therapy and the least family history of asthma (2.8%). Infants with respiratory syncytial virus belonged more frequently to Profile B and D (42.4% and 37.3% respectively).Conclusions: The identification of different clinical endotypes among infants with bronchiolitis might be the first step towards future research regarding the management of the disease and long-term consequences.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA1004.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). %U