RT Journal Article SR Electronic T1 The recent index, timed inspiratory effort can be a new tool to guide the weaning ventilation and extubation successful JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP OA3298 DO 10.1183/13993003.congress-2019.OA3298 VO 54 IS suppl 63 A1 Leonardo Souza A1 Marcos David Godoy A1 Raphaela Cordeiro A1 Jocemir Lugon YR 2019 UL http://erj.ersjournals.com/content/54/suppl_63/OA3298.abstract AB Introduction: The Timed Inspiratory effort index (TIE) can be concluded up to 60 seconds and the Spontaneous breathing test (SBT) could reach 120 minutes. Prolonged weaning exposes patients to extra discomfort, increased risk of complications and raises the cost of hospitalization.Objective: evaluate TIE index as a spontaneous breathing test to guide weaning and extubation through comparative analysis with tradicional T tube breathing test.Methods: Controlled, randomized, prospective study in patients starting the weaning process. Experimental group underwent TIE index to guide weaning/extubation decision up to 60 seconds and control group used traditional T-tube for 30 minutes. The endpoint were successful weaning, re-intubation rate and survival rate in ICU. TIE index were measured using a digital vacuometer (Magnamed, Brazil). Kaplan-Meier curves with log rank tests were used with significance P<0.05.Results: 100 subjects using mechanical ventilation were analyzed, 50 in TIE group (15 male, age 77 ± 16 years, APACHE II score 24 ± 9.6). Success rate at weaning was 74%(37), re-intubation rate 26%(13), death rate in ICU was 24% (12). Control group of 50 patients (24 male, age 66 ± 18 years, APACHE II score 21 ± 8.2), success rate at weaning was 76%(38), re-intubation rate 24%(12), death rate was 24% (12). Thirty days after interventions, survival time for TIE and T-tube groups were: 29.9 (21-39) and 22.7 (9-35) days. Log rank test was not able to record diferences between the groups (P=0.29).Conclusion: The TIE index present the similar relation with T-tube, proving to be a new efficient tool to guide the success of ventilatory weaning and extubation.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, OA3298.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).