TY - JOUR T1 - Cardiometabolic impact and symptom profile of obstructivesleep apnea: does gender matter? JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2019.PA4412 VL - 54 IS - suppl 63 SP - PA4412 AU - Sophia Schiza AU - Izolde Bouloukaki AU - Ozen K Basoglu AU - Tarja Saaresranta AU - Renata Riha AU - Ludger Grote AU - Jan Hedner AU - Oreste Marrone AU - Athanasia Pataka AU - Pascalis Steiropoulos AU - Carolina Lombardi AU - Georgia Trakada AU - Maria R Bonsignore Y1 - 2019/09/28 UR - http://erj.ersjournals.com/content/54/suppl_63/PA4412.abstract N2 - Background: Cardio-metabolic risk and clinical presentation profile in obstructive sleep apnea (OSA) differs between men and women.Objective: To evaluate the influence of gender on OSA-related symptoms and prevalent cardio-metabolic disease in the European Sleep Apnea Database (ESADA) cohort.Methods: We identified a sample of 18,872 patients (mean age 52 years, 30% women) from the ESADA cohort with complete data from polygraphic or polysomnographic recordings and Epworth sleepiness scale (ESS). The predictive value of gender on associated symptoms and prevalent cardio-metabolic disease was investigated after adjustment for relevant confounding factors including age, obesity and comorbidities.Results: Arterial hypertension [odds ratio, OR (95% CI) 1.493 (1.336–1.660), p<0.001] and diabetes [OR (95% CI) 2.281 (1.971–2.638), p<0.001] were more prevalent in female compared to male OSA patients after adjustment for confounders. Women were older than men and had a higher body mass index. However, men had a bigger neck circumference, a higher waist-to-hip ratio and more severe OSA (AHI 29 vs 20/h, p<0.001). Following multivariable adjustment, female gender was independently associated with daytime hypersomnolence (ESS>16) [OR (95% CI) 1.356 (1.198–1.536), p<0.001], a prolonged sleep latency (>30 min) [OR (95% CI) 1.739 (1.576–1.920), p<0.001] and more frequent intake of hypnotics [OR (95% CI) 2.240 (1.949–2.575), p<0.001].Conclusion: In this large clinical patient cohort, cardio-metabolic comorbidities were more prevalent in female compared to male OSA patients. Furthermore, women with OSA are more likely to complain about EDS and report symptoms suggestive for insomnia.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4412.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -