RT Journal Article SR Electronic T1 Differences in allergen-positive reactivity distribution among adults and children in southern China: an investigation based on real-world medical big data JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA2729 DO 10.1183/13993003.congress-2019.PA2729 VO 54 IS suppl 63 A1 Haisheng Hu A1 Baoqing Sun A1 Wenting Luo YR 2019 UL http://erj.ersjournals.com/content/54/suppl_63/PA2729.abstract AB Objective: Allergic diseases are increasing yearly. Using a large sample size of real-world medical data, we aimed to analyze sensitization differences between adults and children in southern China.Methods: We undertook a retrospective analysis of 39,831 patients (adults, n = 22,835; children, n = 16,996) who underwent allergen serum immunoglobulin E (sIgE) testing (ImmunoCAP) from January to December 2017 in several city centers in southern China.Results: In southern China, the highest allergen-positive rate was due to Dermatophagoides pteronyssinus (28.1%), followed by Blattella germanica (24.3%), Penaeus monodon (19.2%), Cancer pagurus (15.8%), and Gallus domesticus (9.9%). The allergen-positive rate was the highest for B. germanica in adults (28.2%) and D. pteronyssinus in children (29.2%). The allergen-positive rates for G. domesticus and Bos domesticus were higher in children than in adults (p < 0.05). The allergen-positive rates for B. germanica, P. monodon, and C. pagurus were higher in adults than in children (p < 0.05). B. germanica were risk factors for various allergic diseases, with a higher allergen-positive rate in most parts of southern China. The allergen-positive rate for fungal allergies in children gradually increased in summer and autumn and reached a maximum rate (6.2%) in October.Conclusion: In southern China, B. germanica were found to be an important allergen associated with several allergic diseases in adults, whereas child patients were primarily allergic to D. pteronyssinus.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA2729.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).