TY - JOUR T1 - Clinical characteristics of physician diagnosed asthma-COPD overlap JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2019.PA4239 VL - 54 IS - suppl 63 SP - PA4239 AU - Hyun Lee AU - Sung Jun Chung AU - Yoomi Yeo AU - Tai Sun Park AU - Dong Won Park AU - Ji Young Moon AU - Tae Hyung Kim AU - Jang Won Sohn AU - Ho Joo Yoon AU - Sang-Heon Kim Y1 - 2019/09/28 UR - http://erj.ersjournals.com/content/54/suppl_63/PA4239.abstract N2 - Purpose: Few studies evaluated in-depth characterization of physician-diagnosed asthma-COPD overlap (ACO), and its clinical differences with asthma or COPD.Methods: A cross sectional study of 417 patients in Hanyang Obstructive Pulmonary diseases Evaluation (HOPE) cohort was performed to compare the clinical characteristics of physician diagnosed ACO, asthma, and COPD.Results: Of the 417 patients, 170(40.8%), 171(41.0%), and 76(18.2%) were diagnosed of asthma, COPD, and ACO, respectively. Compared to patients with other diseases, those with asthma were younger, had lowest prevalence of male, current-smoker, biomass exposure, previous pulmonary tuberculosis, and hypertension, and had highest prevalence of allergic rhinitis, atopic dermatitis, and gastroesophageal reflux. In comparison, COPD patients had lowest body mass index and highest prevalence of previous pulmonary tuberculosis, previous pneumonia, bronchiectasis, and hypertension. ACO patients had highest prevalence of current-smoker. Regarding pulmonary function, FEV1 was highest in patients with asthma, followed by those with ACO, and those with COPD. The proportion of patients with mMRC scores ≥ 2 was most frequent in COPD patients and lowest in asthma patients. While the porportion of patients with positive bronchodilator response was highest in ACO patients, the porportion of positive bronchoprovocation test was highest in asthma patients. Peripheral eosinophil counts and exhaled nitro oxide levels were highest in asthma patients and lowest in COPD patients.Conclusions: Physician-diagnosed ACO patients had highest prevalence of current-smoker and their symptoms, lung function, and eosinophil counts were between the two conditions.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4239.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -