PT  - JOURNAL ARTICLE
AU  - Kateryna Gashynova
AU  - Kseniia Suska
AU  - Valeriia Dmytrychenko
TI  - Microbiome landscape and disease duration role in allergy in adult patients with bronchiectasis
AID  - 10.1183/13993003.congress-2019.PA2763
DP  - 2019 Sep 28
TA  - European Respiratory Journal
PG  - PA2763
VI  - 54
IP  - suppl 63
4099  - http://erj.ersjournals.com/content/54/suppl_63/PA2763.short
4100  - http://erj.ersjournals.com/content/54/suppl_63/PA2763.full
SO  - Eur Respir J2019 Sep 28; 54
AB  - The respiratory microbiome plays a great role in the etiology and pathogenesis of B. Inflammation in B is primarily neutrophilic, but the participation of allergies in the pathogenesis requires further research. The aim of the study was to determine the interconnection between allergy and microbiome landscape and the DD in pts with B.Methods: The study included cohort of pts with confirmed by HRCT B. Total serum (TS) IgE was evaluated by using conventional electrochemiluminescence immunoassay. Isolation and identification of pathogens were conducted by classical bacteriological methods of inoculation on nutrient media. DD was calculated by the pts medical history. The methods of descriptive and non-parametric statistics were used to process the results.Results: 21 pts were examined. Mean age 49.1±14.1years, 33.3% men; mean DD - 12.5±14.9 years. Pathogens were detected in 15(71.4%) samples (s), the combination of pathogens - in 2(9.5%) pts. Pseudomonas aeruginosa (PA) was identified in 7(33.3%) s, Haemophilus influenza (HI) in 7(33.3%) s, Klebsiella pneumoniae in 1(4.7%) s. The elevation of TS IgE was found in 7(33.3%) pts; median level 66.23 [24.8;107.2]. There was found moderate positive correlation between DD and TS IgE (R=0.59; p=0.005). We compared the level of IgE in pts with chronic colonization (G1) and without (G2) and found that in the G1 the level of IgE is statistically significantly higher (p=0,019 by the Mann-Whitney test).Conclusions: 1) The study showed that a longer DD and chronic colonization by pathogens are associated with higher levels of TS IgE in pts with B. 2) The most common pathogens are PA and HI in pts with B in Dnipro.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA2763.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).