TY - JOUR T1 - Quantitative CT based selective Lung-Volume Reduction by prolonged Weaning in COPD GOLD D Patients with massive Emphysema JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2019.PA2188 VL - 54 IS - suppl 63 SP - PA2188 AU - Mehyar Lavae-Mokhtari AU - Omar Alshintiry AU - Joachim Fichter AU - Gabriela May AU - Volker Vieth AU - Nicolas Dickgreber Y1 - 2019/09/28 UR - http://erj.ersjournals.com/content/54/suppl_63/PA2188.abstract N2 - Introduction: The aim of this retrospective analyze was the comparison of quantitative CT and Ventilation-Perfusionscintigraphy to evaluate the validity of quantitative CT as a pre-surgical method in invasive ventilated patients with prolonged weaning before LVR (lung-volume reduction).Methods: From 2013 to 2018 18 patients with COPD GOLD D and massive emphysema obtained quantitative CT and Ventilation-Perfusionscintigraphy. There were 10 male (average age 66 and 34 pack years) and 8 female (average age 67 and 35 pack years) patients.Results: By dividing lung in upper, middle and lower part of each side computer-aided automated analytical software could visualize emphysema by measure lung density (LAV, low – attenuation volume < -950 HU) in percent. Axial and coronal density masks image could show cluster of emphysema. The comparison of quantitative CT and Ventilation-Perfusionscintigraphy presented conformity of 92.86% of results.Discussion: By patients with COPD GOLD D and massive emphysema on respiratory intensive care unit (R-Intensive) with prolonged weaning using invasive ventilation, RSBI > 120 (rapid shallow breating index) and in patients with long term non-invasive ventilation (NIV) the possibility of VIDD (ventilator induced diaphragmatic dysfunction) will increase. In conclusion in invasive ventilated patients with massive emphysema and prolonged weaning selective LVR (lung-volume reduction surgery) based on quantitative CT can relieve the diaphragmatic function, increase the success of the weaning and reduce hospitalization duration.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA2188.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -