TY - JOUR T1 - The relationship of plasma adropin levels in pediatric obese patients with OSA JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2019.PA4979 VL - 54 IS - suppl 63 SP - PA4979 AU - Surya Prakash Bhatt AU - Randeep Guleria AU - S.K Kabra Y1 - 2019/09/28 UR - http://erj.ersjournals.com/content/54/suppl_63/PA4979.abstract N2 - Introduction: Adropin is a hormone that plays an important role in the regulation of glucose homeostasis and lipid. However information on childhood obstructive sleep apnea (OSA) and concentrations of adropin is limited. In this study, we aimed to determine the relation of adropin with clinical, anthropometric parameters and biochemical parameters with OSA in obese children.Material and Methods: In this cross sectional study, we recruited obese children [body mass index (BMI>25kg/m2) identified by screening in pediatric outpatient services of our institution and overnight polysomnography was performed in all children. We recorded demographic, clinical details, anthropometric and biochemical parameters, and estimation of adropin levels in all enrolled patients.Results: A total of 110 children (mean age, male/female) were enrolled. OSA was documented by PSG in 45 % of these childern. We observed significantly high values of body mass index, abdominal obesity (waist and hip circumferences), % body fat, fasting blood glucose, total cholestrol, serum triglyceride, alanine transaminase, alkaline phosphate, fasting insulin and homeostatic model assessment- insulin resistance in children with OSA as compared to obese childern without OSA. A plasma adropin concentrations were also significantly lower in OSA group (p<0.001) as compared to non OSA.Conclusion: Plasma adropin concentrations are reduced in pediatric OSA. Assessment of plasma adropin concentrations may provide a reliable indicator of vascular injury in the context of OSA in children.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4979.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -