PT - JOURNAL ARTICLE AU - Carla Paola Sanchez Rios AU - Jerónimo Rafael Rodríguez Cid AU - Jorge Arturo Alatorre Alexander TI - Frequency and clinical-tomographic characterization of NSCLC with T790M mutation to TKI progression AID - 10.1183/13993003.congress-2019.PA3067 DP - 2019 Sep 28 TA - European Respiratory Journal PG - PA3067 VI - 54 IP - suppl 63 4099 - http://erj.ersjournals.com/content/54/suppl_63/PA3067.short 4100 - http://erj.ersjournals.com/content/54/suppl_63/PA3067.full SO - Eur Respir J2019 Sep 28; 54 AB - Introduction: The acquired resistance to tyrosine kinase inhibitors (TKI’s) in patients with NSCLC (non-small cell lung cancer) occurs in up to 60% of cases. Liquid biopsy is an easy, accurate and safe tool for this determination. These patients should receive targeted therapies capable of evading resistance.Objective: To describe the frequency and tomographic characteristics of patients with NSCLC and T790M mutation after progression in the first line.Methods: Observational, retrospective and transversal study. Review clinical records and radiological file of patients with NSCLC EGFR positive who received first-line tyrosine kinase inhibitors presented disease progression with determination of resistance to TKI T790M by liquid biopsy.Results: Total cohort of patients with lung cancer at the National Institute of Respiratory Diseases it was found that 93.74% (n = 704) belonged to the group of NSCLC, 86% (n = 606) they were adenocarcinomas and 42.63% (n = 191) had positive EGFR. A total of 30 samples were sent for T790M determination due to suspicion of resistance once they had received first line treatment with tyrosine kinase inhibitor, finding positivity in 50%. The majority was female, never smokers. The median progression-free survival was 12 months. The pleural effusion and air bronchogram were the most frequent tomographic findings.Conclusion: In this study, we found a 50% T790M mutation frequency, higher than in other countries. The pleural effusion and the air bronchogram are frequent findings to the progression that could suggest the presence of resistance in T790M.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA3067.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).