RT Journal Article
SR Electronic
T1 What do patients want? Preferences for two asthma regimens in mild/moderate asthma
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4188
DO 10.1183/13993003.congress-2019.PA4188
VO 54
IS suppl 63
A1 Christina Baggott
A1 Jo Hardy
A1 Helen Reddel
A1 Jenny Sparks
A1 Saras Mane
A1 Doñah Sabbagh
A1 Mark Holliday
A1 Robert J Hancox
A1 Richard Beasley
A1 James Fingleton
YR 2019
UL http://erj.ersjournals.com/content/54/suppl_63/PA4188.abstract
AB Introduction: In the SYGMA trials in mild asthma, as needed budesonide-formoterol (BUD/FORM) was non-inferior to regular low-dose budesonide (BUD) plus as-needed terbutaline for preventing severe exacerbations but inferior for symptom control. Patient preference for and satisfaction with a symptom driven regimen are unknown.Aim: To determine preference for and satisfaction with a combined preventer and reliever taken as needed versus twice daily preventer plus as needed reliever, in participants in the PRACTICAL study.Methods: PRACTICAL is a 12-month open-label randomised controlled trial of as-needed BUD/FORM versus regular BUD plus as-needed terbutaline (n=890). Participants finishing the study after 26th March 2018 at 6/14 sites were asked to complete a satisfaction and preference survey at their final study visit.Results: 307 of 407 (75%) eligible participants completed the survey. A combined preventer and reliever inhaler as-needed regimen was preferred by 136/151 (90%) of the as-needed BUD/FORM group vs 63/156 (40%) of the regular BUD group, p<0.0001, 199/307 (65%) overall (Figure 1). Satisfaction with medication effectiveness and speed of onset were high in both treatment arms. Of participants randomised to as-needed BUD/FORM, 92% were confident/very confident in using it as a reliever.Conclusions: Overall patients preferred as-needed BUD/FORM in mild asthma, especially those who had used this for 12 months in the PRACTICAL studyFootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4188.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).