TY - JOUR T1 - Impact of reducing antibiotic treatment on inflammation among patients with community-acquired pneumonia JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2019.PA4546 VL - 54 IS - suppl 63 SP - PA4546 AU - Ane Uranga Echeverria AU - Amaia Artaraz AU - Amaia Bilbao AU - Jose Maria Quinatana AU - Ignacio Arriaga AU - Maider Intxausti AU - Jose Luis Lobo AU - Julia Amaranta Garcia AU - Jesus Camino AU - Pedro Pablo EspaƱa Y1 - 2019/09/28 UR - http://erj.ersjournals.com/content/54/suppl_63/PA4546.abstract N2 - Background: The optimal duration of antibiotic treatment for CAP has not been well established.Objective: To evaluate the impact of reducing duration of antibiotic treatment on inflammation measured by inflammation biomarkers.Methods: This was a multicenter randomized clinical trial to validate IDSA/ATS guidelines for duration of antibiotic treatment. Biomarkers could be analyzed among patients of one hospital at day one, 3-5 days as well as at day 30. Biomarkers were proADM, CRP and PCT. Biomarkers were compared between both groups by means of the non-parametric Wilcoxon test. The comparison was also performed adjusting for biomarkers at 3-5 days by means of the general linear models.Results: The median of days with antibiotics in the control group (150 pt) was 10 days and 5 days in the intervention group (162 pt). Blood samples were obtained among 136 patients for biomarkers measurements, 61 and 75 in the control and intervention group, respectively. There were no differences between both groups for proADM, CRP and PCT, neither at day 5 or at day 30, nor for the changes. Table 1 shows proADM values in the control and the intervention groups. The differences remained non-significant after adjusting.Conclusions: Reducing antibiotic treatment in patients with community-acquired pneumonia does not impact on the decrease of inflammation in the follow-up.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4546.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -