RT Journal Article
SR Electronic
T1 Frequency of relapse rates in rifampicin-resistant tuberculosis in operated patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA5276
DO 10.1183/13993003.congress-2019.PA5276
VO 54
IS suppl 63
A1 Bagdasaryan, Tatevik
A1 Ergeshov, Atadjan
YR 2019
UL http://erj.ersjournals.com/content/54/suppl_63/PA5276.abstract
AB Background: Multidrug-resistant (MDR) and extensive drug-resistant (XDR) tuberculosis (TB) are a complex problem in the world. Surgical treatment increases the chance of curing patients with MDR-TB or XDR.Study Concept: comparing of relapse rates in rifampicin-resistant cases for various periods after surgical chemotherapy.Methods: Retrospective study in CTRI from 2010 to 2011. 62 patients underwent surgical treatment of pulmonary tuberculosis. In all patients, tuberculosis was detected for the first time and MDR or XDR. After surgery, all patients received chemotherapy depending on the drug resistance. In 27 patients, the after surgery chemotherapy course was 6 months (group 1). In 35 patients, the course was 12 months (group 2). Compare frequency of relapse cases in group 1 and 2 patients.Results: In the 1st group there were 6 cases of cavernous pulmonary tuberculosis (22.8%), in the 2nd group - 24 (68.6%) (p1-2<0,01). Patients with tuberculoma in group 1 had 21 (77.8%), in group 2 - 11 (31.4%) (p1-2<0,01). Prior to surgical treatment, all patients received chemotherapy for 6 months. All patients underwent resection of one lung. In group 1, the entire course of treatment was 12 months, in the second group - 18 months. The follow-up period after surgery was 5 years. There were 7 relapses: in group 1 - 3 cases (11.1%), in group 2 – 4 cases (4.4%) (p1-2> 0,1).Conclusions: reduction in chemotherapy after surgery for MDR and XDR-TB from 12 to 6 months does not lead to an increase in the frequency of postoperative relapse.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA5276.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).