PT - JOURNAL ARTICLE AU - Torcato Moreira Marques AU - Inês Moreira AU - André Almeida AU - Teresa Ferreira AU - Catarina Pires AU - Rita Corte Real TI - Mortality among patients admitted for viral lower respiratory tract infections – a seasonal cohort study AID - 10.1183/13993003.congress-2019.PA4560 DP - 2019 Sep 28 TA - European Respiratory Journal PG - PA4560 VI - 54 IP - suppl 63 4099 - http://erj.ersjournals.com/content/54/suppl_63/PA4560.short 4100 - http://erj.ersjournals.com/content/54/suppl_63/PA4560.full SO - Eur Respir J2019 Sep 28; 54 AB - Introduction and Objectives: Viral pathogens are responsible for a considerable burden of seasonal respiratory disease. The aim of this study was to study outcome predictors among patients admitted with severe lower respiratory tract infections (LRTI’s).Methods: We included all patients >65 years-old admitted from December 2017 to April 2018 at a teaching hospital presenting with an LRTI and having a positive viral PCR on nasal and oropharyngeal swabs. Baseline co-morbidities outcomes of admissions were assessed.Results: There were 355 admissions meeting the inclusion criteria. Median age was 78 years (interquartile range 67-85) and the majority were females (57% n=221). Cardiac failure was reported as a co-morbidity in 87 patients (23%) and chronic obstructive lung disease (COPD) or asthma in 101 (26%). Influenza A was identified in 150 samples (39%), mostly (71%) H3N2; Influenza B in 184 (48%); respiratory syncytial virus (RSV) in 59 (15%). There were 16 (4%) patients submitted to invasive mechanical ventilation (IMV), 33 (9%) to non-invasive ventilation (NIV) and 32 (8%) who died during the course of admission. History of COPD or asthma and cardiac faliure was significantly associated with both IMV and NIV (p<0.05 on chi square test), but not with mortality (p>0.05). RSV infection was associated with higher mortality, even after adjustment for demographics and co-morbidities on multivariate regression (aOR 3.0 CI95%[1.3-6.9]).Conclusions: In this cohort of elderly patients, those with cardiac failure and COPD or asthma were more prone to being submitted to NIV or IMV. RSV infection was associated with higher mortality independently of significant co-morbidities.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4560.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).