RT Journal Article SR Electronic T1 Outcomes among immunecompetent and immunocompromised and pneumonia and trachea-bronchitis in mechanical ventilation JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA2277 DO 10.1183/13993003.congress-2019.PA2277 VO 54 IS suppl 63 A1 Maria Augusta Costa deMoura A1 João Moura A1 Virginia Moura A1 Marilia Moura A1 Roberto Stirbulov YR 2019 UL http://erj.ersjournals.com/content/54/suppl_63/PA2277.abstract AB Introduction: Mechanical ventilation(MV) offers different risks of infections such as pneumonias(VAP) and ventilator-associated trachea-bronchitis(VAT) in intensive care unit (ICU) patients.Objective: To verify if immunocompetent and immunocompromised under mechanical ventilation present different clinical outcomes in VAT and VAP.Method: prospective cohort study in immunocompetewnt and imunocompromised patients under mechanical ventilation for morethan 48 hours. Pulmonary infecyion score (CPIS)≥6 was usedfor VAT or VAP. For quantitative variables, absolute and relative frequencies. we applied Studentt’s t, non-parametric Mann-Wittney, Fisher exact and Sperman for correlations, odds ratio for logistic regression and Kaplan Meier for survival.Results: In 30 months,822 patients were admitted to the ICU, of which 481 under mechanical ventilation, 204 due to compliance with 102 for each group. In immunocompetent patients 12,8% of VAP and 8,3% of VAT were found for 1000 days of MV and risks associated wiht mechanical time and ICU. In immunocompromised patients 18,6% survived and evolved wiht 14,1% and VAT of 7% for 1000 days of MV with risk associated only wiht sepsis. Pseudomonas aeruginosa, Acinetobacter baumannii and Klebisiellas pneumoniae were the predominant in the two groups.Conclusion: VAT has a similar clinical couse to VAP, with greater precocty and mortality in immunocopromised patients. Immunocompetent patients have VAP determined by increased exposure to mechanical ventilation and ICUFootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA2277.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).