PT  - JOURNAL ARTICLE
AU  - Wang, I-Duo
AU  - Tsai, Pei-Yi
AU  - Peng, Chung-Kan
AU  - Chung, Chi-Hsiang
AU  - Liu, Feng-Cheng
AU  - Chang, Shan-Yueh
AU  - Chien, Wu-Chien
TI  - Association of obstructive sleep apnea with female infertility - A 13-year nationwide population-based retrospective study
AID  - 10.1183/13993003.congress-2019.PA901
DP  - 2019 Sep 28
TA  - European Respiratory Journal
PG  - PA901
VI  - 54
IP  - suppl 63
4099  - https://publications.ersnet.org//content/54/suppl_63/PA901.short
4100  - https://publications.ersnet.org//content/54/suppl_63/PA901.full
SO  - Eur Respir J2019 Sep 28; 54
AB  - Study Objectives: Obstructive sleep apnea (OSA) increases the risk of hypertension, type 2 diabetes mellitus (DM), cardiovascular diseases and stroke. In the previous study, we have shown that non apnea sleep disorder associates with increased risk of female infertility. However, the risk of OSA to female infertility has not been thoroughly understood. Our study aimed to determine whether OSA increases subsequent risk of female infertility.Methods: Our study utilized the outpatient and inpatient data from Taiwan’s National Health Insurance Research Database between 2000 and 2013. We enrolled 4,078 females aged 20 to 45 years old and diagnosed with female infertility in the end. 1,946 of them who matched our criteria were assigned to the study group. We retrospectively investigated those who had previous exposure to OSA. We used multivariable logistic regression analysis to estimate the effects of OSA on female infertility.Results: The OSA cohort had an adjusted hazard ratio (HR) of female infertility 2.154-fold higher than that of the cohort without sleep disorders. In the stratified age group, the OSA group had the highest impact on 31- to 35-year-olds, with an adjusted HR of 2.690 (p=0.049).Conclusions: Our study provides a nationwide, population based, 13-year retrospective data demonstrating that OSA patients are at a higher risk of female infertility.Keywords: Obstructive sleep apnea; Female infertility; Taiwan National Health Insurance Research Database; Longitudinal Health Insurance DatabaseFootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA901.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).