RT Journal Article
SR Electronic
T1 Mixed apnea metrics during diagnostic polysomnographies in obstructive sleep apnea patients with/without treatment-emergent central sleep apnea
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA824
DO 10.1183/13993003.congress-2019.PA824
VO 54
IS suppl 63
A1 Herkenrath, Simon
A1 Pavsic, Katja
A1 Treml, Marcel
A1 Hagmeyer, Lars
A1 Randerath, Winfried
YR 2019
UL http://erj.ersjournals.com/content/54/suppl_63/PA824.abstract
AB Mixed apneas (MA) are characterized by absent respiratory effort and airflow in the first section of the event and respiratory effort without airflow in the last section. The pathophysiology is based on coexisting ventilatory control instability and upper airway collapsibility.Diagnostic polysomnographies (PSG) from 17 male OSA patients with/without treatment-emergent central sleep apnea (TE-CSA) were retrospectively analyzed to determine breathing pattern metrics (figure 1). TE-CSA was defined as central apnea-hypopnea index ≥10/h during positive airway pressure therapy initiation. Duty ratio (DR), a surrogate for the loop gain, was calculated as ventilatory duration/cycle duration.Figure 1. Analyzed metrics of mixed apnea breathing cyclesView this table:Table 1. Results (mean±standard deviation).Conclusion: MA metrics in diagnostic PSGs differ significantly between patients with/without TE-CSA. TE-CSA patients show longer apneic durations, more frequent arousals, shorter VD and smaller DR, consistent with higher ventilatory control instability.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA824.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).