PT - JOURNAL ARTICLE AU - Taeyun Kim AU - Hyunji Choi AU - Jehun Kim AU - Hyo-Jung Kim AU - Chul-Ho Oak AU - Tae-Won Jang AU - Maan-Hong Jung TI - The Effect of Lipid Profile and Obesity on the Grade of Neutropenia in Patients with Small Cell Lung Cancer Treated with Etoposide-Cisplatin as First Regimen AID - 10.1183/13993003.congress-2019.PA4657 DP - 2019 Sep 28 TA - European Respiratory Journal PG - PA4657 VI - 54 IP - suppl 63 4099 - http://erj.ersjournals.com/content/54/suppl_63/PA4657.short 4100 - http://erj.ersjournals.com/content/54/suppl_63/PA4657.full SO - Eur Respir J2019 Sep 28; 54 AB - Background: The standard regimen for extensive stage small cell lung cancer (SCLC) is Etoposide (EPS)-Cisplatin (CIS). Most patients develop neutropenia after chemothearpy. Severe neutropenia causes poor outcomes in infection, hospitalization, or morbidity.Aims: Therefore, it is important to predict the degree of neutropenia and to identify the factors affecting it.Methods: We retrospectively collected medical records from 131 patients diagnosed with SCLC between 2006 and 2015. All patients received EPS for 3 days and CIS for 1 day as primary regimen. Baseline body mass index (BMI), high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, and triglyceride (TG) level was measured. After 2 to 3 chemotherapies, computed tomography scans were used to evaluate the response. The correlation between lipid profile and grade of neutropenia and the effect of the grade of neutropenia on chemotherapy response were analyzed.Results: The greater the degree of neutropenia, the better the treatment response was. There were no significant correlations between the levels of HDL (P-value 0.123), LDL (P-value 0.578), TG (P-value 0.857) and BMI (P-value 0.735).Conclusions: As previously reported, we confirmed that the greater the degree of neutropenia, the better the treatment response. However, the effect of patient’s BMI, TG, LDL, and HDL on neutropenia was not statistically significant. Since predicting the degree of neutropenia is important, we will continue our efforts to find relevant factors.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4657.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).