RT Journal Article
SR Electronic
T1 Asthma exacerbation patterns in middle-aged and older adults; the Rotterdam Study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA5070
DO 10.1183/13993003.congress-2019.PA5070
VO 54
IS suppl 63
A1 Emmely W. de Roos
A1 Lies Lahousse
A1 Arfan Ikram
A1 Bruno Stricker
A1 Guy Brusselle
YR 2019
UL http://erj.ersjournals.com/content/54/suppl_63/PA5070.abstract
AB Background: Few studies have examined the natural history of asthma exacerbations in an ageing population, most have focused on younger patients or severe patient cohorts.Methods: Subjects with doctors diagnosed asthma in the Rotterdam Study, a population-based cohort from January 1991 to May 2018 were assessed for asthma exacerbations. Participants were aged 45 years or above. Characteristics of exacerbators versus non-exacerbators were depicted. Exacerbation risk factors were appraised using time dependent cox-regression.Results: Mean follow-up time was 13.87 years. Out of 763 participants with asthma did 427(56.0%) experience at least one exacerbation. Mean exacerbation rate in the entire cohort was 0.22. We demonstrate seasonality in the exacerbation distribution pattern, independent of eosinophil status. Median exacerbation free survival time was 9.8 years. Risk factors for exacerbations entailed prior exacerbation, age, use of respiratory medication, spirometry, respiratory complaints and smoking status.Conclusion: Within a population based cohort of middle-aged and older asthmatics with long term follow-up not all suffer exacerbations. Impaired lung function, persistent smoking, history of exacerbations and respiratory complaints are associated with an increase in exacerbation rates.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA5070.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).