PT  - JOURNAL ARTICLE
AU  - Mauro Maniscalco
AU  - Cecilia Calabrese
AU  - Maria D’Amato
AU  - Antonio Molino
AU  - Maria Aliani
AU  - Alberto De Felice
AU  - Fabio Ricciardolo
AU  - Elisiana Carpagnano
TI  - Association between exhaled nitric oxide and nasal polyposisin severe asthma
AID  - 10.1183/13993003.congress-2019.PA2622
DP  - 2019 Sep 28
TA  - European Respiratory Journal
PG  - PA2622
VI  - 54
IP  - suppl 63
4099  - http://erj.ersjournals.com/content/54/suppl_63/PA2622.short
4100  - http://erj.ersjournals.com/content/54/suppl_63/PA2622.full
SO  - Eur Respir J2019 Sep 28; 54
AB  - Background: Although several contributions exist on the role of fractional exhaled NO (FeNO) in diagnosis and management of asthma, no studies have analysed the association between FeNO in patients with severe asthma and nasal polyposis.Aim: We investigated the potential association between FeNO and the presence of nasal polyps in patients affected by severe asthma.Methods: Study population included 93 severe asthmatic adult patients consecutively enrolled from four Italian specialist clinic centres from 2015 and 2018. In these patients lung function, asthma control, FeNO, blood eosinophils and CT scan of paranasal sinuses were evaluated.Results: Nasal polyposis was observed in 28 patients (30%). Among univariate predictors (lower BMI, higher FeNO, eosinophil and neutrophil count), recursive partitioning analysis identified as best predictors of nasal polyposis high values of eosinophil count (≥6.5%) and FeNO (≥39 ppb). The 40 patients with low eosinophil count (<6.5%) and FeNO (<39 ppb) had a significant lower occurrence of nasal polyposis than those with higher values (8% vs 58%; p<0.001). The stratification algorithm had a good performance in discriminate patients with and without nasal polyposis (area under the receiver operating characteristic curve of 0.768).Conclusions: Our results show that, beyond the expected relationship with eosinophils counts, FeNO significantly contributed to the presence of nasal polyps in patients with severe asthma.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA2622.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).