PT  - JOURNAL ARTICLE
AU  - Suhani Patel
AU  - Claire M Nolan
AU  - Ruth E Barker
AU  - Sarah E Jones
AU  - Stephanie C Wynne
AU  - Jessica A Walsh
AU  - Peter M George
AU  - Toby M Maher
AU  - William D-C Man
TI  - Does daily physical activity levels or functional exercise capacity provide additional prognostic information in idiopathic pulmonary fibrosis (IPF)?
AID  - 10.1183/13993003.congress-2019.PA3419
DP  - 2019 Sep 28
TA  - European Respiratory Journal
PG  - PA3419
VI  - 54
IP  - suppl 63
4099  - http://erj.ersjournals.com/content/54/suppl_63/PA3419.short
4100  - http://erj.ersjournals.com/content/54/suppl_63/PA3419.full
SO  - Eur Respir J2019 Sep 28; 54
AB  - Background: Lung function measures remain the most reliable markers of prognosis in IPF. Measures of functional exercise capacity (eg. six-minute walk distance: 6MWD) and physical activity levels (eg. daily step count) may provide additional prognostic information.Methods: In 94 patients with IPF, 6MWD, daily step count (averaged over 5 days measured with SenseWear™ activity monitor), forced vital capacity (FVC) and Gender Age Physiology (GAP) index were recorded. Survival status data were collected over one year. Cox regression was used to identify predictors of mortality. Receiver Operating Characteristic curves were constructed for mortality, and area under curve (AUC) were compared.Results: Baseline characteristics: 84% male; (mean(SD)): age 72(±7) years; FVC 74(±20) %predicted; 6MWD 392(±103) m, daily step count 3478(±2425), 13% prescribed ambulatory oxygen. FVC %predicted alone had good discrimination for 1-year mortality (AUC: 0.78). On multivariable analysis, a model incorporating FVC %predicted and step count <2047 had an AUC of 0.82, and a model incorporating FVC %predicted, step count <2047 and BMI had an AUC of 0.87. This was better than for GAP index (AUC=0.56). 6MWD did not provide additional prognostic information to FVC %predicted alone.Conclusion: Daily step count, but not 6MWD, provides additional prognostic information to FVC %predicted.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA3419.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).