RT Journal Article
SR Electronic
T1 Health-related quality of life in lung cancer patients: validation of a national version of EORTC QLQ-LC29 questionnaire
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP OA3789
DO 10.1183/13993003.congress-2019.OA3789
VO 54
IS suppl 63
A1 Luca Bertolaccini
A1 Marcello Giani
A1 Enrico Ruffini
A1 Massimo Torre
A1 Lorenzo Rosso
A1 Paola Faverio
A1 Fabrizio Minervini
A1 Marco Scarci
YR 2019
UL http://erj.ersjournals.com/content/54/suppl_63/OA3789.abstract
AB Introduction: European Organisation for Research and Treatment of Cancer (EORTC) quality of life questionnaire (QLQ) is integrated system for assessing health-related quality of life (HRQL) of lung cancer (LC) patients participating in clinical trials. EORTC developed QLQ-instrument for cancer patients (QLQ-C30) and LC-specific (QLQ-LC13) that assesses specific LC symptoms/treatments.Aim: To validate national versions of EORTC LC-specific questionnaires.Methods: Patients completed instruments before/after LC surgery (24 hours, 15 days and 30 days). Internal reliability (Cronbach’s α)+Kaiser-Meyer-Olkin (KMO) sampling adequacy ratio were used. Areas under receiver operating characteristic (ROC) curves estimated discriminating value. Statistical analyses were made using R 3.5.2 (standard, rcmdr, EZR, scoring.QLQLC29, scoring.QLQLC13, scoring.QLQL30 packages).Results: 51 patients completed questionnaires with high compliance rates. Homogeneity of questionnaires showed high correlation with total scale. ROC (Figure 1) showed no significative differences between questionnaires (p=0.862). KMO ratio (Figure 2) was 0.7477 (QLQ-C30), 0.863 (QLQ-LC29), 0.8793 (QLQ-LC13). Reliability (Cronbach’s α) reaches 0.5988 (QLQ-C30), 0.8755 (QLQ-LC29), 0.8020 (QLQ-LC13).Conclusion: EORTC questionnaires are reliable and valid for HRQL evaluation in LC patients and can be widely employed in national clinical studies.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, OA3789.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).