PT  - JOURNAL ARTICLE
AU  - Luca Bertolaccini
AU  - Marcello Giani
AU  - Enrico Ruffini
AU  - Massimo Torre
AU  - Lorenzo Rosso
AU  - Paola Faverio
AU  - Fabrizio Minervini
AU  - Marco Scarci
TI  - Health-related quality of life in lung cancer patients: validation of a national version of EORTC QLQ-LC29 questionnaire
AID  - 10.1183/13993003.congress-2019.OA3789
DP  - 2019 Sep 28
TA  - European Respiratory Journal
PG  - OA3789
VI  - 54
IP  - suppl 63
4099  - http://erj.ersjournals.com/content/54/suppl_63/OA3789.short
4100  - http://erj.ersjournals.com/content/54/suppl_63/OA3789.full
SO  - Eur Respir J2019 Sep 28; 54
AB  - Introduction: European Organisation for Research and Treatment of Cancer (EORTC) quality of life questionnaire (QLQ) is integrated system for assessing health-related quality of life (HRQL) of lung cancer (LC) patients participating in clinical trials. EORTC developed QLQ-instrument for cancer patients (QLQ-C30) and LC-specific (QLQ-LC13) that assesses specific LC symptoms/treatments.Aim: To validate national versions of EORTC LC-specific questionnaires.Methods: Patients completed instruments before/after LC surgery (24 hours, 15 days and 30 days). Internal reliability (Cronbach’s α)+Kaiser-Meyer-Olkin (KMO) sampling adequacy ratio were used. Areas under receiver operating characteristic (ROC) curves estimated discriminating value. Statistical analyses were made using R 3.5.2 (standard, rcmdr, EZR, scoring.QLQLC29, scoring.QLQLC13, scoring.QLQL30 packages).Results: 51 patients completed questionnaires with high compliance rates. Homogeneity of questionnaires showed high correlation with total scale. ROC (Figure 1) showed no significative differences between questionnaires (p=0.862). KMO ratio (Figure 2) was 0.7477 (QLQ-C30), 0.863 (QLQ-LC29), 0.8793 (QLQ-LC13). Reliability (Cronbach’s α) reaches 0.5988 (QLQ-C30), 0.8755 (QLQ-LC29), 0.8020 (QLQ-LC13).Conclusion: EORTC questionnaires are reliable and valid for HRQL evaluation in LC patients and can be widely employed in national clinical studies.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, OA3789.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).