TY - JOUR T1 - Close correlation between cumulative corticosteroid dose and weight gain in a German cohort of sarcoid patients JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2019.PA1390 VL - 54 IS - suppl 63 SP - PA1390 AU - Lena Kenn AU - Rosa-Marie Apel AU - Bendedikt Jaeger AU - Antje Prasse Y1 - 2019/09/28 UR - http://erj.ersjournals.com/content/54/suppl_63/PA1390.abstract N2 - The aim of the study was to test if there is a correlation between the average prednisolone dose in the first treatment year and weight gain in patients with sarcoidosis.Method: data of 100 consecutive patients with biopsy confirmed sarcoidosis who presented at our ILD clinic at Hannover Medical School were included into our study. Most of these patients were referred to our center in a later disease stage. Although some of our patients had their initial diagnosis and first treatment period up to 25 years ago, most of them had their corticosteroid treatments quite precisely recorded. Lung function parameters, weight gain and corticosteroid dosing were obtained from patient records, files, and telephone interviews.Results: of the 100 consecutive patients 80 had received corticosteroids in the first year after initial diagnosis. Mean cumulative prednisone dose in the first year of treatment was 4463 mg and we observed a high variability. As suggested by the recently published Dutch group we also used 4000mg as a cut-off value. In our cohort 33% of the patients were treated with a cumulative prednisone dose above 4000mg. Mean weight gain in the first year of treatment was 5.8 kg. In most of the patients the main increase in weight gain was recorded for the first year of treatment with corticosteroids. We observed a highly significant correlation between weight gain and cumulative prednisone dose (p<0.01, r=0.68).Conclusion: our data are in line with recently published Dutch data showing a statistically significant correlation between cumulative prednisone dose and weight gain in sarcoid patients.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA1390.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -