TY - JOUR T1 - Prevalence of relevant multi-drug resistant (MDR) pathogens in a bronchiectasis (BE) cohort JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2019.PA4580 VL - 54 IS - suppl 63 SP - PA4580 AU - Javier Perez AU - Eva Polverino AU - Antonio Alvares AU - Patricia Chang AU - Letizia Traversi AU - Ariadna Rando AU - Daniel Romero AU - Maria Teresa Martin Y1 - 2019/09/28 UR - http://erj.ersjournals.com/content/54/suppl_63/PA4580.abstract N2 - Background: 60% of BE patients suffer bronchial infection, leading to frequent antibiotics and high risk of MDR.Aim: to describe the prevalence of MDR S. aureus (SA) and P. aeruginosa (PA) in a cohort of BE patients from Barcelona (Spain).Methods: Inclusion criteria: age ≥18y, documented BE, at least 1 sputum culture along 2018. According to EUCAST (PMID: 21793988) isolates were classified as susceptible (S) or MDR (R≥3 antibiotic categories).Results: 198 patients were included; 71 had ≥1 positive sputum culture. 53 (26.8%) and 23 (11.6%) had ≥1 PA or SA isolate respectively (Fig1). 11/53 patients carried MDR PA (20.8%) and 10/11 had MDR PA in previous years). The least active drugs against MDR PA were Piperacillin-Tazobactam and 3rd/4th gen. cephalosporins (91.7% R each), ciprofloxacin (75%R), and aminoglycosides (50%R). Colistin was the most active against PA (94.8%S). Only 6 patients (20%) carried Oxacilin R SA.Factors associated with MDR PA were ≥2 exacerbations in the previous year (OR=8.5;95%CI:1.9-38.4; p=0.005) and increased severity scores (E-FACED 6-9, OR=7.5; 95%IC=1.1–52.4; p=0.041). Chronic inhaled antibiotics showed a trend to association with MDR PA (OR=2,6; 95%IC:0.65-10.2;p=0.178). Non significant trends were observed for MDR SA.Conclusions: MDR infections are prevalent and associated with frequent use of antibiotics and disease severity. Strategies to reduce the risk of MDR in BE are needed.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4580.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -