RT Journal Article
SR Electronic
T1 Number needed to treat (NNT) to have an additional patient free from a severe or moderate/severe exacerbation: post-hoc analysis of SYGMA 1 in mild asthma
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3716
DO 10.1183/13993003.congress-2019.PA3716
VO 54
IS suppl 63
A1 Fitzgerald, Mark
A1 O’Byrne, Paul M.
A1 Bateman, Eric D.
A1 Barnes, Peter J.
A1 Zhong, Nanshan
A1 Alagappan, Vijay
A1 Whelan, Glenn
A1 Lamarca, Rosa
A1 Puu, Margareta
A1 Reddel, Helen K.
YR 2019
UL http://erj.ersjournals.com/content/54/suppl_63/PA3716.abstract
AB Introduction: Exacerbations can occur even in mild asthma. The risk of exacerbations can be reduced with as-needed budesonide/formoterol (BUD/FORM) or BUD maintenance+as-needed terbutaline vs as-needed terbutaline alone (SYGMA 1; NCT02149199).Aims and Objectives: This post-hoc analysis of SYGMA 1 examined the NNT with as-needed BUD/FORM or BUD maintenance to have an additional patient (pt) free from a severe or moderate/severe exacerbation over 1 year.Methods: SYGMA 1 was a 52-week, double-blind trial of pts with mild asthma randomised to placebo bid+terbutaline 0.5mg as needed (n=1277), placebo bid+as-needed BUD/FORM 200/6µg (n=1277) or BUD 200µg bid+as-needed terbutaline (n=1282). The NNT for as-needed BUD/FORM and BUD maintenance vs as-needed terbutaline after 1 year of treatment were compared.Results: When compared with as-needed terbutaline, treating 16 pts with as-needed BUD/FORM, or 17 pts with maintenance BUD, for 1 year, prevented 1 additional pt having a severe exacerbation, reducing to 9 and 10 pts, respectively, for moderate/severe exacerbations (Table).Conclusions: The numbers needed to treat for a year with as-needed BUD/FORM to prevent one pt having a severe or moderate/severe exacerbation vs as-needed terbutaline were comparable to BUD maintenance, regardless of pre-study treatment, supporting a role for these therapies in mild asthma.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA3716.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).