PT  - JOURNAL ARTICLE
AU  - Matt Gani
AU  - Thiago Bassi
AU  - Linda Clark
AU  - Doug Evans
AU  - Elizabeth Rohrs
AU  - Karen Stephens
AU  - Kaity Taylor
AU  - Viral Thakkar
AU  - Adrián Ebner
TI  - Late Breaking Abstract - Transvenous stimulation thresholds of the left and right phrenic nerves using a single catheter via jugular access
AID  - 10.1183/13993003.congress-2019.PA2275
DP  - 2019 Sep 28
TA  - European Respiratory Journal
PG  - PA2275
VI  - 54
IP  - suppl 63
4099  - http://erj.ersjournals.com/content/54/suppl_63/PA2275.short
4100  - http://erj.ersjournals.com/content/54/suppl_63/PA2275.full
SO  - Eur Respir J2019 Sep 28; 54
AB  - Introduction: An investigational electrophrenic transvenous neurostimulation respiration (ETNR) catheter (LIVE Catheter®, Lungpacer®) and phrenic nerve stimulator device were studied for the safety and feasibility of catheter insertion/removal, and left/right ETNR. The catheter insertion point was the left jugular vein, instead of the left subclavian vein.Methods: 13 subjects were consented, enrolled, anesthetized and mechanically ventilated. The catheter was placed prior to the scheduled elective surgical procedure, inserted in the left internal (n=9) or external (n=4) jugular vein. Placement was confirmed by fluoroscopy. After confirming phrenic nerve capture, stimulation was delivered in the ventilator’s inspiratory phase, causing diaphragm contractions. After evaluation, the catheter was removed. Safety was assessed based on adverse events.Results: Phrenic nerve capture was observed in all 13 patients (n=11, left and right; n=2, right-only). Stimulation thresholds were equivalent left and right (1551±959nC, n=11; 1711±1174nC, n=13; p=0.37). The insertion point was easily accessed. Stimulation of captured phrenic nerves resulted in diaphragm contraction. The catheter was easily removed. No device- or procedure-related adverse events were noted during the study, post-procedure, or at two-week follow-up.Conclusions: Safety and feasibility of ETNR via jugular access were confirmed. Effective ETNR was observed in all patients evaluated. Stimulation thresholds were equivalent for the left and right phrenic nerves, indicating that there was no negative impact on left phrenic nerve capture due to the tortuosity of the catheter pathway when inserted in the left jugular vein.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA2275.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).