TY - JOUR T1 - Pulmonary thrombosis occurring in hypobaric hypoxia among previously healthy young adult males JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2019.PA1466 VL - 54 IS - suppl 63 SP - PA1466 AU - Mahaveera Bnbm Prasad AU - Y Uday Y1 - 2019/09/28 UR - http://erj.ersjournals.com/content/54/suppl_63/PA1466.abstract N2 - 9 healthy male low landers aged between 23 years to 31 years were inducted to Himalayan ranges located between 16000 feet to 18000 feet above mean sea level after due process of acclimatization. After a mean stay of 2 weeks they developed acute respiratory failure. Clinically had cyanosis, tachypnea, tachycardia and crepitaions over both lung fields. Chest skiagram revealed prominent proximal pulmonary vascular markings with patchy alveolar infiltrates bilaterally suggestive of acute pulmonary edema while ECG showed sinus tachycardia, right axix deviation and non specific T wave changes. All had pulmonary arterial thrombosis as revealed by echocardiogram with one showing thrombus in right ventricle. Emergency therapy with high flow oxygen, low molecular heparin and short stay inside hyperbaric chamber improved the clinical condition of all of them. Subsequently all were evacuated to lower altitudes and followed up by echocardiogram and chest skiagram. All recovered completely at three months and none had any coagulation abnormality on detailed thrombotic workup. This study suggests that high altitude is an independent risk factor for thrombotic state and can occur within few weeks of high altitude sjourn.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA1466.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -