RT Journal Article
SR Electronic
T1 PFBIO — a prospective longitudinal IPF cohort
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4710
DO 10.1183/13993003.congress-2019.PA4710
VO 54
IS suppl 63
A1 Nils Hoyer
A1 Thomas Skovhus Prior
A1 Elisabeth Bendstrup
A1 Torgny Wilcke
A1 Saher Burhan Shaker
YR 2019
UL http://erj.ersjournals.com/content/54/suppl_63/PA4710.abstract
AB Background: Prospective cohort studies of patients with idiopathic pulmonary fibrosis (IPF), with longitudinal follow-up and the collection of biospecimen, can bridge the gap between short clinical trials of highly selected patients and traditional IPF registries, often with retrospective design and lack of complete data.Aims: To create a prospective IPF cohort with minimal selection bias and longitudinal collection of blood samples.Methods: The PFBIO cohort is a prospective cohort of incident IPF patients with data collection and blood sampling at baseline, 6 months, 12 months and annually hereafter for five years. Patients are recruited immediately after the IPF diagnosis and prior to any antifibrotic treatment. Recruitment started in April 2016 and is still ongoing.Results: During its first three years, the PFBIO cohort has included 202 patients with IPF at the two largest IPF centers in Denmark. It has included patients with both mild and advanced disease, and the data are close to complete (Table 1).Conclusion: Baseline data from the currently included patients show a cohort which spans the entire disease spectrum of IPF. In addition to two currently ongoing studies about diagnostic delay and novel prognostic biomarkers, the cohort is contributing to a growing biorepository available for clinical and translational research and collaborations.View this table:Table 1. Baseline characteristics and completeness of data.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4710.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).