TY - JOUR T1 - The comparison of diagnostic relevance of protein C, C-reactive protein and endothelin-1 for prediction of lung vessel thrombosis in patients with community-acquired pneumonia JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2019.PA4575 VL - 54 IS - suppl 63 SP - PA4575 AU - Kseniia Bielosludtseva AU - Tetiana Pertseva AU - Tetiana Kireieieva AU - Mariia Krykhtina Y1 - 2019/09/28 UR - http://erj.ersjournals.com/content/54/suppl_63/PA4575.abstract N2 - The aim was to evaluate the diagnostic value of serum levels of endothelin 1 (ET-1), protein C(PC), and C-reactive protein(CRP), D-dimer (DD) for prediction of lung vessel thrombosis in patients with CAP.Methods: This was a prospective observational study in 75 adults (80% men), who were hospitalized owing to CAP. The severity of CAP was assessed using the SMRT-CO scale.Results: 34 patients (45,3%) had severe CAP (patients had 3,0[3,0–5,0] scores according to the SMRT-CO scale). Serum levels of ET-1, D-D and CRP were significantly higher in patients with severe CAP than in patients with mild CAP (patients had 0,0[0,0–1,0] scores according to the SMRT-CO scale) (p<0,05 for all comparisons). Levels of PC were lower in patients with severe CAP compared with those with mild CAP, but the difference was not significant (p=0,347).At a cut-off point of ≤63%, PC showed a sensitivity-66,7%, a specificity-89,3% (AUC=0,836, p<0,001), at a cut-off point of>0.842, ET-1 showed a sensitivity-71,4% and a specificity-58,3%.(AUC =0,567, p=0.534), at a cut-off point of>520 ng/mL, D-D showed a sensitivity-86,7% and a specificity-88,9% (AUC=0,889, p<0,001) and at a cut-off point of>296,68 mg/L, CRP showed a sensitivity-85,7% and a specificity-33,3% (AUC=0,565, p=0.519), as a determinant of the lung vessel thrombosis.Conclusions: ET-1, PC, DD and CRP at admission appear to be useful biomarkers for assessing the risk of lung vessel thrombosis in severe CAP.All hospitalized patients with CAP, who have the level of PC lower than 63% have high risk of thrombosis and need to receive anticoagulant treatment.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4575.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -