TY - JOUR T1 - The utility of Endobronchial Ultrasound-Transbronchial Needle Aspiration (EBUS-TBNA) in Programmed Death Ligand-1 (PDL-1) analysis of Non-Small Cell Lung Cancer (NSCLC) JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2019.PA4682 VL - 54 IS - suppl 63 SP - PA4682 AU - Fawad Hameed AU - Alastair Moore AU - Anny Sykes AU - John Wrightson Y1 - 2019/09/28 UR - http://erj.ersjournals.com/content/54/suppl_63/PA4682.abstract N2 - Introduction: The EBUS-TBNA is a minimally invasive technique widely used in the diagnosis, staging and immunohistochemistry analysis of lung cancer.1PDL-1 is a checkpoint on NSCLC that can be targeted with immunotherapy.2Routine PDL-1 testing was introduced at Oxford University Hospital NHS Foundation Trust (OUHFT) in 2017 and it is unclear if EBUS-TBNA provides adequate tissue for testing. In our current practice at the OUHFT, all NSCLC cases (Squamous Cell Lung Carcinoma and Lung Adenocarcinoma) identified on cytopathology are subsequently tested for PDL-1 tumour percentage score (TPS). The aim of this study was to see whether or not EBUS-TBNA samples provide adequate tissue for PDL-1 testing.Material and Methods: We retrospectively reviewed PDL-1 results of all NSCLC patients diagnosed by EBUS-TBNA during the year 2018 at OUHFT.Results: A total of 27 cases were diagnosed to have NSCLC on EBUS-TBNA samples in 2018. Out of 27,a total of 22 cases were tested for PDL-1. Of the 5 not tested,4 were not suitable for treatment and 1 had alternative sampling prior to EBUS.Of 22 tested cases, 17(77.2%) had adequate EBUS-TBNA sample for PDL-1 testing. 5(22.8%) were non-diagnostic due to insufficient sample.The TPS was negative(<1%) in 7 out of 17 cases(41%), low(1-49%) in 6 out of 17 cases(27.7%) and positive(≥50%) in 4 out of 17 cases(23.5%).Conclusion: In OUHFT, the EBUS-TBNA appears an effective technique for providing sufficient sample for PDL-1 testing in a majority of patients(77.2%). This is a small sample and it is unclear whether or not there were problems with non-diagnostic EBUS-bronchoscopies.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4682.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -