TY - JOUR T1 - Bronchiolitis obliterans - a review of this rare paediatric respiratory disorder JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2019.PA1013 VL - 54 IS - suppl 63 SP - PA1013 AU - Jennifer Burrows AU - Rebecca Thursfield Y1 - 2019/09/28 UR - http://erj.ersjournals.com/content/54/suppl_63/PA1013.abstract N2 - Background: Bronchiolitis obliterans (BO) is a rare form of chronic obstructive lung disease that follows and insult to the lower respiratory tract, often a viral infection and most commonly adenovirus. There are surprisingly little data on the clinical course and outcome, and physiological state of this group.Aims: The aim of this review was to establish the number of patients with BO at Alder hey Children’s Hospital, the cause and clinical course of these patients.Methods: A letter search from 2010 was carried out and diagnosis confirmed by reviewing the electronic patient records (EPR). EPR were then used to collate clinical data including presenting symptoms, microbiology and respiratory physiological investigation.Results: 58 patients were identified with a mean age at presentation to tertiary respiratory services 44 months, and mean age at diagnosis was 51 months. All patients had diagnosis confirmed with clinical history and compatible CT chest findings; one child underwent lung biopsy. Adenovirus was the most common organism to have been identified prior to diagnosis with 14% of patients isolating this. Respiratory function was significantly reduced with a mean FEV1 of 63.7% and mean FVC 78.6%. 2 patients had undergone further respiratory physiology testing; one with an overnight TOSCA (CO2/O2) study and the other a TOSCA study and hypoxic challenge testing. There was no consensus on management with 74% patients receiving inhaled steroids, 71% oral antibiotics and 15% intravenous antibiotics.Conclusion: This case series demonstrates that this group have severely limited respiratory function and would benefit from further research to establish physiological state and guidelines for optimal management.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA1013.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -