%0 Journal Article %A Benjamin Seeliger %A Klaus Stahl %A Markus Busch %A Olaf Wiesner %A Tobias Welte %A Marius M. Hoeper %A Matthias Eder %A Albert Heim %A Sascha David %T Immunosuppression is associated with lower morbidity and mortality in the 2017/2018 influenza epidemic %D 2019 %R 10.1183/13993003.congress-2019.PA4561 %J European Respiratory Journal %P PA4561 %V 54 %N suppl 63 %X Background: Impact of immunosuppression on outcomes in influenza is insufficiently understood.Aims and Objectives: To analyze morbidity and mortality of immunocompetent (IC) vs immunosuppressed (IS) patients with influenza A and B in the 2017/2018 epidemic.Methods: 231 patients with influenza infection evaluated in a German tertiary care hospital were analyzed retrospectively for hospitalization, intensive care unit (ICU) admission and mortality. IS patients were either organ transplant recipients or patients on chemotherapy.Results: In total, 188 (81%) patients needed hospitalization and 34 patients (15%) were admitted to the ICU. Hospitalization (71 vs 91%, p<0.001) and ICU admission (8 vs 22%, p=0.002) were less frequent in the IS compared to the IC group in all influenza cases. For influenza A, the IS-group was less frequently admitted to ICU (9 vs 33%, p=0.029); for influenza B, overall hospitalization was less frequent in the IS-group (70 vs 93%, p<0.001), while ICU admission rates were similar. Overall mortality was 6% (13/231); 6 had influenza A (10%) and 7 had influenza B (4%). Mortality was significantly lower in the IS-group (Hazard Ratio 3.124 (1.051-9.284), p=0.038). The difference was more pronounced in the Influenza A group (Hazard ratio 5.146 (0.989-26.77), p=0.052).Conclusions: We observed that IS was associated with less morbidity and mortality, in influenza, especially type A.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4561.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). %U