@article {SeeligerPA4561, author = {Benjamin Seeliger and Klaus Stahl and Markus Busch and Olaf Wiesner and Tobias Welte and Marius M. Hoeper and Matthias Eder and Albert Heim and Sascha David}, title = {Immunosuppression is associated with lower morbidity and mortality in the 2017/2018 influenza epidemic}, volume = {54}, number = {suppl 63}, elocation-id = {PA4561}, year = {2019}, doi = {10.1183/13993003.congress-2019.PA4561}, publisher = {European Respiratory Society}, abstract = {Background: Impact of immunosuppression on outcomes in influenza is insufficiently understood.Aims and Objectives: To analyze morbidity and mortality of immunocompetent (IC) vs immunosuppressed (IS) patients with influenza A and B in the 2017/2018 epidemic.Methods: 231 patients with influenza infection evaluated in a German tertiary care hospital were analyzed retrospectively for hospitalization, intensive care unit (ICU) admission and mortality. IS patients were either organ transplant recipients or patients on chemotherapy.Results: In total, 188 (81\%) patients needed hospitalization and 34 patients (15\%) were admitted to the ICU. Hospitalization (71 vs 91\%, p\<0.001) and ICU admission (8 vs 22\%, p=0.002) were less frequent in the IS compared to the IC group in all influenza cases. For influenza A, the IS-group was less frequently admitted to ICU (9 vs 33\%, p=0.029); for influenza B, overall hospitalization was less frequent in the IS-group (70 vs 93\%, p\<0.001), while ICU admission rates were similar. Overall mortality was 6\% (13/231); 6 had influenza A (10\%) and 7 had influenza B (4\%). Mortality was significantly lower in the IS-group (Hazard Ratio 3.124 (1.051-9.284), p=0.038). The difference was more pronounced in the Influenza A group (Hazard ratio 5.146 (0.989-26.77), p=0.052).Conclusions: We observed that IS was associated with less morbidity and mortality, in influenza, especially type A.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4561.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/54/suppl_63/PA4561}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }